KMID : 1161520210250060347
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Animal Cells and Systems 2021 Volume.25 No. 6 p.347 ~ p.357
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Inositol Requiring Enzyme (IRE), a multiplayer in sensing endoplasmic reticulum stress
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Zhou Zhixin
Wang Qian Michalak Marek
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Abstract
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The endoplasmic reticulum (ER) can sense a wide variety of external and internal perturbations and responds by mounting stress coping responses, such as the unfolded protein response (UPR). The UPR is composed of three stress sensors, namely IRE1¥á, PERK, and ATF6 that are activated to re-establish ER homeostasis. IRE1¥á represents the most ancient branch of the UPR affecting many cellular processes in plant and animal cells. IRE1¥á is a type I transmembrane protein with kinase/nuclease activities in response to ER stress. Both the ER luminal and cytosolic IRE1¥á interactomes have been identified revealing a multifunctional role of the ER stress sensor. IRE1¥á is also associated with organellar membrane contacts to promote rapid communication between intracellular organelles under stress conditions.
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KEYWORD
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IRE1¥á, unfolded protein response, endoplasmic reticulum, stress sensor
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